Author(s):
The field of nanomedicine has witnessed transformative advancements with the integration of nanoscale biomaterials for precise therapeutic delivery. This review explores the emerging role of engineered nanomaterials in facilitating the targeted delivery of CRISPR-Cas9 gene-editing tools, a breakthrough technology in genome editing. By addressing key challenges such as off-target effects, immune responses, and delivery efficiency, nanoscale systems— including lipid nanoparticles, polymeric carriers, and hybrid nanocomposites—offer unprecedented control over cellular targeting and intracellular trafficking. These innovations hold the potential to revolutionize therapeutic interventions for genetic disorders, cancers, and infectious diseases, providing a pathway toward safer and more effective geneediting applications. Future directions focus on optimizing biocompatibility, improving in vivo targeting specificity, and advancing clinical translation of these precision nanomedicine strategies
