Author(s):
Personalized cancer immunotherapy has emerged as a transformative approach to combat cancer, focusing on tailoring treatments to individual patients. A critical challenge lies in effectively modulating the tumor microenvironment (TME) to overcome immune suppression and enhance therapeutic efficacy. Biodegradable scaffolds, particularly those incorporating advanced nanomaterials, offer innovative solutions for precise TME modulation. These scaffolds enable localized and sustained delivery of immunomodulatory agents, while their biodegradable nature minimizes long-term side effects. This review explores cutting-edge nanomaterial-based scaffolds designed for personalized cancer immunotherapy, highlighting their role in reshaping the TME, promoting immune activation, and advancing patient-specific therapeutic strategies. Future directions and translational challenges are also discussed, emphasizing the potential of these approaches to revolutionize cancer treatment.
